Our expertises

Discovery of molecules active on a specific biological target, development and application of novel computational methodologies to discover new biologically relevant compounds.

Synthesis

Multicomponent reactions

Aryne chemistry

Isocyanide chemistry

Click chemistry

In silico

Chemoinformatics algorithms

Molecular simulations

Virtual screening

De novo drug design

Identification of molecules

SAR studies

Molecular probes

Compound library design

Drug repositioning

 

Research topics

Tubulin

Anti-Colchi site compounds

HDAC

Zn-chelating agents

NMPRTase

Anticancer compounds

PI3K

ATP mimetics

Click chemistry

Fast, simple reactions

MCR

Multicomponent Reactions

The Team

Every member is indipendent and free to follow his/her research interests, undertake collaborative projects and independently publish.

Gian Cesare Tron

Professor

His research interests concern the discovery of new multicomponent reactions and their applications in the field of medicinal chemistry and the discovery of new antitumoral agents (tubulin inhibitors, HDAC inhibitors, NAD+ syntesis inhibitors).

Tracey Pirali

Professor

Her main area of interest is the synthesis of bioactive compounds of medicinal relevance, especially in the realm of cancer treatment (tubulin, phosphatidylinositol 3-kinases, istone deacetylases, indoleamine 2,3-dioxygenase). Recently, she has been interested in the development of novel ligands for TRP channels.

Alberto Massarotti

Associate professor

His research interests include the development and application of novel computational methodologies to discover new lead compounds.
 

Ubaldina Galli

Associate professor

Her research interests have shifted through the years from the synthesis on NO-donors as antimalaric and antiulcer drugs to the synthesis of selective PI3 kinases inhibitors as antitumoral, antiinflammatory and anticoagulant drugs.

Rita Di Martino

Assistant professor








Irene Preet Bhela

Ph.D. student

Tutor: Prof.ssa T. Pirali






Georgia Goutsiou

Ph.D. student

Tutor: Prof.ssa T. Pirali






Sarah-Jane Rezzi

Ph.D. student

Tutor: Prof.ssa T. Pirali






Francesca Brunelli

Ph.D. student

Tutor: Prof. G.C. Tron






Laura Gioiello

Ph.D. student

Tutor: Prof.ssa T. Pirali

Marco Brentazzoli

Fellow

Tutor: Prof. G.C. Tron






Claudia Ielmini

Fellow

Tutor: Prof. G.C. Tron

Marko Koten

Fellow

Tutor: Prof.ssa T. Pirali

Federico Occhipinti

Undergraduate student

Tutor: Prof.ssa T. Pirali

Sara Minorello

Undergraduate student

Tutor: Prof.ssa T. Pirali

Lisa Accomazzi

Undergraduate student

Tutor: Prof. G.C. Tron

Matteo Chiodini

Undergraduate student

Tutor: Prof.ssa T. Pirali

Matteo Bonan

Undergraduate student

Tutor: Prof. G.C. Tron

Debora Mazzoni

Undergraduate student

Tutor: Prof.ssa T. Pirali

Riccardo Fizzotti

Undergraduate student

Tutor: Prof. G.C. Tron

Pietro Grungo

Undergraduate student

Tutor: Prof.ssa T. Pirali

Luca Zacchi

Undergraduate student

Tutor: Prof. G.C. Tron

Alberto Croci

Undergraduate student

Tutor: Prof. G.C. Tron

Rebecca Rana

Undergraduate student

Tutor: Prof.ssa T. Pirali

 

Publications

Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vector Anopheles gambiae overexpressed in the reproductive tissues

Curr Res Struct Biol 2022, 4, 246-255

Verza A., Miggiano R., ..., Del Grosso E., Galli U., Rizzi M., Rossi F.

Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity

Molecules 2022, 27, 6218-

Nichugovskiy A., ..., Tron G.C., Maslov M.

In-water synthesis of isocyanides under micellar conditions

Green Chemistry 2022, 24, 7022-7028

Brunelli F., Aprile S., Russo C., Giustiniano M., Tron G.C.

Contact Us

  • Address: L.go Donegani 2, 28100 Novara (Italy)
  • Phone: +39 0321 375 857
  • Fax: +39 0321 375 621
  • Email: info@symech.it